Hyphenated techniques as tools for speciating biological metals: metallo- thionein and metal-binding proteins
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چکیده
منابع مشابه
Detection of proteins by hyphenated techniques with endogenous metal tags and metal chemical labelling.
The absolute and relative quantitation of proteins plays a fundamental role in modern proteomics, as it is the key to understand still unresolved biological questions in medical and pharmaceutical applications. Highly sensitive analytical methods are required to quantify proteins in biological samples and to correlate their concentration levels with several diseases. Enzyme-linked immunosorbent...
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Alzheimer's disease (AD) is the most prevalent age-related dementia affecting millions of people worldwide. Its main pathological hallmark feature is the formation of insoluble protein deposits of amyloid-β and hyperphosphorylated tau protein into extracellular plaques and intracellular neurofibrillary tangles, respectively. Many of the mechanistic details of this process remain unknown, but a ...
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The fact that metal-binding proteins are a consequence of elevated metal concentration in organisms is well known. What has been overlooked is that the presence of these proteins provides a unique opportunity to reformulate the criteria of metal pollution. The detoxification effect of metal-binding proteins in animals from polluted areas has been cited, but there have been only very few studies...
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(Humic/Fulvic Acid) has the capability of transferring metals to and from metallo-proteins in vivo. These proteins play a role in metal storage and sequester excess metal ions, preventing toxicity. Metallo-protein concentrations are the highest in the liver where metals accumulate in the metallo-thionein portions of this organ. Metallo-proteins can be found in many other human tissues, includin...
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The expression of metal-binding proteins or peptides in microorganisms and plants in order to enhance heavy metal accumulation and/or tolerance has great potential. Several different peptides and proteins have been explored. This review focuses on cadmium (Cd) because of the significant importance of this metal and because of its global presence in many food materials.
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ژورنال
عنوان ژورنال: Analusis
سال: 1998
ISSN: 0365-4877,1286-482X
DOI: 10.1051/analusis:1998148